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Sr. Scientist - Off Target Characterization and Genomics

South San Francisco, CA 94080

Posted: 04/27/2023 Employment Type: Direct Hire Industry: Scientific Job Number: 11205 Pay Rate: $145k - $170k

Job Description

Our client is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation.

  • As a Senior Scientist, you will enable the characterization and quantitation of unintended off-target genome editing with CRISPR using high throughput next-generation sequencing (NGS) and other methodologies.
  • You will work on various genetic disease areas across different stages of therapeutic development.

Roles and Responsibilities: 
  • Conceptualize, thoroughly plan, and present study project plans with little oversight.
  • Evaluate, develop, and execute genome-wide off-target characterization experiments to support guide characterization for therapeutic development.
  • Efficiently use Amplicon-seq, RNA-seq, Whole Exome-seq, Whole Genome-seq, Genome-wide seq, Translocation-seq, ChIP-Seq, and genome-wide methylation assay for off-target characterization and other studies.
  • Apply extensive scientific knowledge and broad laboratory skills to execute complex bench experiments using a variety of molecular biology, cell biology, and general laboratory techniques.
  • Troubleshoot and optimize, both independently and in collaboration, with colleagues.
  • Accurately document project and sample information, protocols, and experimental details.
  • Collaborate with Quality Control and Quality Assurance teams to generate technical study reports supporting regulatory filings (IND or CTA equivalent).
  • Participate in regulatory interaction meetings, responses to questions from regulators, and strategic communication of off-target characterization results.
  • Interact with and assist other members of the team as needed to meet research objectives. 
  • Oversees activities and assists with training more junior research personnel.

Job Requirements

  • Ph.D. degree (in Biology, Genetics, or a related life sciences field), 3+ years of NGS technologies and workflows experience in the industry.
  • Produce demonstration datasets and execute primary analysis for collaborations. 
  • Participate in the preparation of marketing collateral to support product launches including peer-reviewed publications, application notes, protocols, webinars, and posters.  
  • Previous experience with DNA analysis/genomics applications in NGS, qPCR, or CRISPR is required.
  • Previous experience with publishing scientific papers in peer-reviewed journals is preferred. 
  • Previous experience with regulatory agencies (FDA, OTAT, etc.) or regulatory filing preferred.
  • Excellent organizational skills, ability to multi-task and work cross-functionally.
  • Strong organizational skills and attention to detail. 

Meet Your Recruiter

Lexie Pierce

As a Compass recruiter, Lexie brings in 15 years of experience in leadership and employee growth and development. She's incredibly passionate about helping candidates find and accept new opportunities, ultimately leading her to start her recruiting career in the life science industry. Her favorite part about connecting with Compass candidates and clients is witnessing the excitement the candidates exude and making an impact on their lives.


Outside of the office, Lexie enjoys going to the farmers' market on Saturdays with her son so she can find the best produce to use in her family dinners. She enjoys cooking, reading, knitting, restoring furniture, and spending time with her family and friends. Lexie is also passionate about supporting organizations that are looking to educate the community about Congenital Heart Defects (CHD).

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