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Scientist II - Cancer Immunotherapy Reverse Translation

South San Francisco, CA 94080

Posted: 04/06/2023 Employment Type: Contract Industry: Research and Discovery Job Number: 11180 Pay Rate: $51.00 - $99.00

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

  • We seek a talented and motivated contract Scientist to join our department.
  • Our team aims to develop next generation therapeutic strategies and targets by mining our clinical datasets for new insights into how malignancies respond or resist existing cancer immunotherapy treatments, and then validating those associations in vitro and in vivo.
  • In this role, you will work with both computational and lab-based scientists to plan, conduct, and analyze in vitro studies in support of both high-priority projects and the Company's broader cancer immunotherapy assets.
  • Specifically, you will help develop assays and platforms to screen new drug targets coming out of our clinical datasets, and you will also help engineer the model systems that will be used to validate hits from those screens.

  • Plan, conduct, and analyze in vitro assays to test and validate key mechanistic hypotheses and therapeutic targets identified by the team.
  • Support the onboarding and development of novel molecular and cellular tools and technologies to support your projects.
  • Support additional project work such as cell culture, flow cytometry, western blotting, and ELISAs.
  • Present to and participate at team, department, and other meetings to support project development and decision making.
  • Publish your work in high quality journals.

Job Requirements

Who you are:
  • Bachelors or Masters degree in cell biology, immunology, oncology, or a related field.
  • Demonstrated expertise and at least 3 years of hands-on laboratory experience with in vitro assay development, immunoassays, and/or cutting-edge genomic techniques.
  • Proficiency in molecular biology, such as basic cloning techniques, western blotting, ELISAs, single gene or library-based CRISPR KO design (either non-viral RNP or lentiviral delivery), and RNA preparations for qRT-PCR or bulk RNA-seq applications. Cell labeling and sample preparation for single cell RNA-sequencing is recommended but not required.
  • Experience with cell culture, small molecule handling and dosing, lentiviral/retroviral transductions, multi-color flow cytometry (with an emphasis on CyTek spectral cytometry), FACS-based cell sorting (with an emphasis on BD FACSAria and FACSMelody platforms).
  • Experience with immune cell functional assays, human PBMCs, and ex vivo mouse tissue preparations is recommended but not required.
  • Stellar communication and time management skills. Ability to work collaboratively.
  • Track record of success as evidenced by publications and/or sustained contributions in a biotechnology or pharmaceutical setting.

Meet Your Recruiter

Melissa Politron

As a Compass Recruiter, Melissa "Mel" is excited about rediscovering her passion in helping candidates find opportunities that will excel their professional lives and improve their personal lives. She brings a deeply-rooted excitement to the team by understanding the people she works with and finding ways she can support them. Mel's connections with others inspires her to make a difference in the overall well being of her colleagues, candidates and clients alike. 

Outside of Compass, Mel enjoys cooking, dancing and being a mom to her three wonderful boys. She has an obsession with home organization and thoroughly enjoys solving other families' organizational needs. Mel is also very passionate about One Heart Source, a humanitarian organization that combats conditions such as poverty, diseases and illiteracy through education. She participated as a summer volunteer teacher in Tanzania and credits the organization for shaping her into the person she is today. 

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