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SD_Scientist I

San Diego, CA 92111

Posted: 05/12/2026 Employment Type: Contract Industry: Research and Discovery Job Number: 12634 Pay Rate: $34.00 - $45.00 Remote Friendly: Onsite

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

Role Overview:

We seek an outstanding candidate to join the Gene Therapy Nanotechnology team. The Scientist I will contribute to our cutting-edge delivery platform by designing, preparing, and characterizing ligand conjugates and targeted lipid nanoparticles. A critical component of this role is supporting targeted delivery systems through bioconjugation chemistry, including preparing protein conjugates and formulating targeted LNPs. Responsibilities include executing bioconjugations (e.g., antibodies, peptides) with small molecules or polymers; validating and purifying bioconjugates via LC-TOF and ÄKTA purification station; formulating non-targeted and targeted LNPs encapsulating nucleic acids using microfluidic or T-junction mixing technologies; performing surface bioconjugation for targeted LNPs; supporting analytical assay development (BLI, fluorescence microscopy, ÄKTA); evaluating ligand and particle stability under various conditions; maintaining electronic laboratory notebooks; and authoring SOPs.

Skills:
  • Extensive hands-on experience in bioconjugation methodologies, process optimization, and bimolecular reaction kinetics.
  • Prior expertise in Antibody-Drug Conjugate (ADC) development is strongly preferred.
  • Proven experience with lipid nanoparticle formulation and LNP characterizations via RiboGreen, Dynamic Light Scattering (DLS), and Zeta potential measurement.
  • Proficiency in bioconjugation and formulating buffers is required.
  • Excellent attention to detail and ability to produce consistent results and effectively communicate with cross-functional teams.
  • Proficiency in MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable.
  • Excellent oral and written communication skills.

Job Requirements

Education:
  • MS with 2+ years or BS with 5+ years in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or a related scientific discipline (an equivalent combination of education and experience may be considered).

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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