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Scientist I/II, Investigative Toxicology

South San Francisco, CA 94080

Posted: 03/07/2024 Employment Type: Contract Industry: Research and Discovery Job Number: 11632 Pay Rate: $30.00 - $52.00

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions.  They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

Job Description Summary:

This position is in the Investigative Toxicology Group within the department of Safety Assessment in our client's Research and Early Development organization. The mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed non-clinically and/or in clinical trials through hypothesis driven research. This process involves closely collaborating with scientists across the organization to support the overall safety assessment for our novel therapeutics spanning drug discovery through clinical development and marketing. The group provides fit-for-purpose wet lab-based investigation to address target safety assessment, lead optimization, and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches. As such, we are constantly establishing new platforms and technologies to support a constantly changing portfolio, novel modalities, and emerging therapeutic area needs. We are looking for a highly motivated candidate to work in collaboration with other researchers in the Investigative Toxicology lab.

Duties:
  • This individual will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings and performing assays which may include assessments of cytotoxicity and metabolic changes of cells, capturing cell culture images using high content imaging, flow cytometry, and other technologies.
  • This individual will be working with cells from a broad range of tissues (immune cells, blood, liver, vascular, ocular, immortalized cell lines) and is expected to make detailed observations related to experiments, perform, analyze data, and interpret results.
  • This individual will contribute scientific insights and work in projects related to peer review publications. 
  • This laboratory-based role involves performing, qualifying, and implementing biological assays and technologies to support the Investigative Toxicology group.
  • Candidate will provide scientific and technical support to assays and platforms supported by the Investigative Toxicology group by:
    • Performing experiments involving: immortalized and primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. Experience with these methodologies is desirable, but not required.
    • Maintaining documentation related to protocol execution and results.
    • Writing protocols and contributing to final reports as appropriate.
    • Adhering to departmental SOPs to ensure study integrity and quality.
    • Conducting experiments with a high level of independence and initiative.
    • Performing tasks with minimal direct supervision for routine methods and studies commonly employed by the team.

Job Requirements

Skills:
  • 1-3+ years of laboratory experience with hypothesis-driven research.
  • Ability to analyze, integrate, and present data in a presentation is required.
  • Experience with immortalized and/or primary cell culture, cell viability assessment, Luminex/ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry is highly desired.
  • Experience with complex in-vitro model systems is highly desired.
Education:
  • Bachelors (BS/BA) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline is required.
  • Masters (MS) degree is desirable, but not required.

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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