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Scientist 1

South San Francisco, CA 94080

Posted: 05/14/2024 Employment Type: Contract Industry: Research and Discovery Job Number: 11702 Pay Rate: $44.00 - $52.00 Remote Friendly: Onsite

Job Description

Job Overview:

The departments of Biomolecular Research and Structural Biology, within the our client's Protein Sciences organization are looking for a versatile, dynamic, self-motivated individual to join us as a Scientist 1. The selected individual will contribute towards recombinant protein expression and purification efforts to support drug discovery activities. This role will facilitate expression analysis of novel protein encoding constructs, by building, developing and utilizing automated high throughput processes for expression, purification and characterization for research and portfolio projects. In this collaborative role, the successful candidate will have the opportunity to work with other scientists and group leaders within and outside our department to fulfill protein production needs.

Job Responsibilities:
  • Protein purification using a variety of chromatographic techniques (affinity, size
  • exclusion, ion exchange) for structural and biochemical studies.
  • Screening and optimizing expression and purification of challenging membrane proteins using detergent lysis.
  • Using various expression platforms such as E.coli, insect cells (BEVS), and mammalian expression platforms for small and medium scale protein production.
  • Performing SDS-PAGE, western blot, protein characterization assays by different
  • biophysical and biochemical methods.
  • Operating and maintaining High performance liquid chromatography systems (HPLC) for protein purification and analysis.
  • Performing gel analysis, capturing and interpreting data, uploading results to LIMS databases and sharing with stakeholders.
  • Communicating with and presenting to collaborators and stakeholders across the Protein Sciences organization.

Job Requirements

Required Qualifications:
  • Applicants with a Masters degree in the Biological Sciences should have at least 3-4 years of scientific experience and applicants with a PhD degree (Biochemistry, Biophysics, Cell Biology, Molecular Biology) should have at least 1-2 years of relevant experience.
  • Strong protein purification expertise in affinity and size exclusion chromatography.
  • Strong aseptic cell culture techniques for handling routinely insect and mammalian cells.
  • Ability to think critically, analyze results, plan experiments and carry out troubleshooting as needed.
  • Strong desire to learn new techniques, advance technologies related to protein
  • optimization and interest in implementing new expression systems.
  • Demonstrated ability to work independently in a team-oriented setting
  • Expertise with automation and high-throughput process development will be a plus.
  • Excellent verbal and written communication skills.
  • Excellent organizational skills.

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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