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Scientist, Protein Engineering

South San Francisco, CA 94080

Posted: 12/12/2022 Employment Type: Direct Hire Industry: Research and Discovery Job Number: 10003 Pay Rate: $120k - $130k

Job Description

Our client is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation.


  • Engineer target proteins for desirable therapeutic properties, including improved function, altered target specificity and reduced immunogenicity.
  • Design and build libraries of CRISPR proteins using protein engineering methodologies.
  • Develop screening assays (in vitro and in vivo) and selection methods to characterize engineered protein variants.
  • Collaborate closely with internal teams of varying expertise (including Bioinformatics, Therapeutics, and Functional Genomics) and external academic groups to bring therapeutic proteins to market.

Job Requirements

  • Deep understanding of protein biochemistry, mechanism, or structure that can be applied to functional improvement.
  • Experience in in vitro or in vivo assay development or development of selection systems.
  • Initiative to propose creative, new approaches to improve the performance of therapeutic proteins.
  • Strong molecular biology skills (molecular cloning, DNA and RNA handling, etc.).
  • Strong communication and collaboration skills.
  • Established expertise in protein engineering or directed evolution techniques.
  • Knowledge of CRISPR systems and mechanisms.
  • Experience with mammalian cell culture.


  • PhD in Chemical Biology, Biology, Biochemistry or a related field, with 0+ years of post-graduate experience.

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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