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Research Technician II

South San Francisco, CA 94080

Posted: 10/30/2025 Employment Type: Contract Industry: Research and Discovery Job Number: 12422 Pay Rate: $22.00 - $33.00 Remote Friendly: Onsite

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

Role Overview:

The Department of Structural Biology within Protein Sciences is a world-leading research and drug discovery organization focusing on cutting-edge biomedical questions. We pursue challenging and important problems that aim to uncover fundamental biological mechanisms that would advance our understanding of human physiology in health and disease. We are fully equipped with state-of-the-art facilities, including cryo-electron microscopy (cryoEM) suite with two Titan Krios and two Glacios electron microscopes, among other tools essential for successful structural biology workflows.

The Opportunity:

We are seeking a motivated scientist interested in using structural biology to understand the molecular mechanisms of large macromolecular complexes involved in DNA repair processes. The role involves protein purification, reconstitution, and structure determination of DNA-protein complexes using cryoEM. Additionally, you will help to develop functional biochemical assays to assess and determine the mechanism of action of various multi-subunit protein complexes. You will be highly encouraged to think deeply about the biological problem, make significant intellectual contributions to the chosen research project, and work closely with other team members. It is an exceptional opportunity to pursue basic and drug-discovery questions in a well-resourced biotechnology environment.

Why join us:
  • Be at the forefront of research and drug discovery with unparalleled resources.
  • Highly collaborative, stimulating, and fast-paced environment.
  • Enhance your skills and career with drug discovery experience at the world-leading biotechnology company, with an exceptional opportunity to publish your findings.

Job Requirements

Qualifications.
  • BS/MS degree with 3-5 years of experience or a PhD with 0-2 years of experience in Biochemistry, Chemical Biology, Structural Biology, or a related discipline.
  • Hands-on experience designing and optimizing the purification of challenging protein targets (including protein complexes) for structural and/or functional studies.
  • Development of functional biochemical and biophysical assays.
  • Experience in cryoEM sample and grid preparation (beneficial qualification).
  • Experience with mammalian cell culture functional assays (beneficial qualification).

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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About South San Francisco, CA

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