Search Jobs

Find your next opportunity today.

Research Associate III

South San Francisco, CA 94080

Posted: 05/14/2024 Employment Type: Contract Industry: Research and Discovery Job Number: 11694 Pay Rate: $31.00 - $52.00 Remote Friendly: Onsite

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions.  They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

Role Overview:

This position is in the Investigative Toxicology Group within the department of Safety Assessment in our client's Research and Early Development organization. The mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed non-clinically and/or in clinical trials through hypothesis driven research. This process involves closely collaborating with scientists across the organization to support the overall safety assessment for our novel therapeutics spanning drug discovery through clinical development and marketing. The group provides fit-for-purpose wet lab-based investigation to address target safety assessment, lead optimization, and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches. As such, we are constantly establishing new platforms and technologies to support a constantly changing portfolio, novel modalities, and emerging therapeutic area needs.

Duties:
  • We are looking for a highly motivated candidate to work in collaboration with other researchers in the Investigative Toxicology lab.
  • The Investigative Toxicology groups goal is to use ex vivo and in vitro tools to assess safety liabilities and mechanisms of toxicity observed pre-clinically to support the entire portfolio spanning discovery through development.
    This laboratory-based role involves performing, qualifying and implementing biological assays and technologies to support the Investigative Toxicology group.
    They will also contribute to ongoing efforts to understand the impact of complex-in-vitro models in hazard id and liability assessment.
  • This individual must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings, treating and performing assays to assess cytotoxicity and metabolic changes of cells, capturing cell culture images using confocal and high content imaging.
  • This individual will be working with cells from a broad range of tissues (liver, GI, vascular, ocular) and is expected to make detailed observations related to experiments, perform, analyze data, and interpret results.
  • He/she will contribute with scientific insights and also work in projects related to peer review publications.
  • The individual will also participate in projects related to the development of microfluidics platforms to support toxicity testing for our drug discovery program.
  • Candidate will provide scientific and technical support to assays and platforms supported or under development by the Investigative Toxicology group by:
    • Performing experiments involving: immortalized and primary cell culture, cell viability assessment, ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. Experience with these methodologies is desirable, but not required.
    • A large portion of the cell culture work conducted will focus on the use of organoid or other complex in-vitro model (CIVM) systems.
    • Maintaining documentation related to protocol execution and results.
      Writing protocols and contributing to final reports as appropriate.
    • Adhering to departmental SOPs to ensure study integrity and quality.
      Conducting experiments with a high level of independence and initiative.
    • Performing tasks with minimal direct supervision for routine methods and studies commonly employed by the team.

Job Requirements

Qualifications:
  • This is an ideal position for a researcher who is enthusiastic about learning and contributing to projects with a broad range of techniques. As such the position requires excellent communication and collaboration skills, a desire to learn about and integrate multiple aspects of drug toxicity, and a passion for lab-based research.
  • In particular a candidate who will be successful in this role will be able to collaborate with subject matter experts to collaboratively design a scope of work and key performance indicators for a research project, but then independently drive forward the experimental work including towards identified milestones.
  • Additionally, the success in this role will require flexibility and a willingness to learn new model systems as well as initiative to troubleshoot unexpected experimental results or limitations.

Technical Experience Requirements:
  • 1-3+ years of laboratory experience with hypothesis-driven research.
  • Ability to analyze, integrate, and present data in a presentation is required.
  • Experience with immortalized and/or primary cell culture, cell viability assessment, ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry is highly desired.
  • Experience with complex in-vitro model systems is highly desired.

Education:
  • Bachelors (BS/BA) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline is required; Masters (MS) degree is desirable, but not required.

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

Apply Online

Send an email reminder to:

Share This Job:

Related Jobs:

Login to save this search and get notified of similar positions.

About South San Francisco, CA

Ready to take the next step in your career journey? Explore our job opportunities in the vibrant area surrounding South San Francisco, California! Known for its proximity to the iconic Golden Gate Bridge and the bustling tech hub of Silicon Valley, this region offers unrivaled growth potential and a dynamic work environment. With a unique blend of culture, including the renowned SFMOMA art museum, the lively Castro District, and delectable cuisine like the famous sourdough bread at Boudin Bakery, South San Francisco is the perfect place to thrive professionally while enjoying the beauty of nearby parks like Golden Gate Park and the breathtaking views of the Pacific Ocean. Join us in discovering the endless possibilities for your career in this enchanting region!