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Research Associate II

South San Francisco, CA 94080

Posted: 08/08/2024 Employment Type: Contract Industry: Research and Discovery Job Number: 11763 Pay Rate: $27.00 - $50.00 Remote Friendly: Onsite

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

Job Overview:

We are seeking a dedicated and independent Scientist 2/3 with strong molecular biology skills and experience in the design and assembly of antibody encoding plasmids for expression from mammalian cells.  This is a hands-on, lab-based position that requires close collaboration with colleagues in the Antibody Engineering and is in support of various projects across multiple functions in Research.  

Duties:
  • Work with other scientist focused on discovery, developing, and engineering therapeutic antibody candidates.
  • Apply molecular biology skills to drive the rapid assembly of antibody encoding plasmids for expression from mammalian cells.
  • Collaborate in developing high throughput plasmid assembly solutions for various complex, and multi-specific antibody designs.
  • Collaborate with automation engineers to build and develop workflows for high throughput, automated processes for DNA plasmid assembly and clonal mAb selection.
  •  Interact with informatic engineers to develop processes that support automated antibody development workflows including antibody (DNA and protein sequence) registration, tracking, archiving, and inventory.

Job Requirements

Who You Are:
  • The successful candidate will have a B.S. or M.S. degree in molecular biology or related science and 4+ years of applying molecular biology skills, preferably in an antibody research or industrial setting.
  • Have a basic understanding of antibody therapeutics including IgGs (variable heavy and light chains and constant region), FAbs, bispecific antibodies, and VHH antibodies).
  • Experience and expertise in performing polymerase chain reactions (PCR), general DNA plasmid construct assembly, steps necessary for antibody clone isolation including bacterial transformation, bacterial colony picking, bacterial clone culturing, plasmid purification at the mini to maxi scale, and analyzing DNA sequences.
  • Experience in working with tools for antibody DNA sequence analysis, sequence confirmation, and sequence alignment is essential.
  • Basic molecular biology skills in DNA ligation, DNA mutagenesis, oligonucleotide design, and endonuclease restriction digestion analysis are also required. Experience with surface plasmon resonance (SPR), performing binding ELISAs and graphing is preferred.
  • The candidate must have excellent record keeping skills, strong communication skills, and be experienced in data management using Excel or Google Drive.

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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About South San Francisco, CA

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