Research Associate I
1 DNA Way South San Francisco, CA 94080 | Contract
Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world' s leading biotech companies, with multiple products on the market and a promising development pipeline.
- We have an opening for a talented Scientific Researcher/Senior Scientific Researcher to join our Biochemical and Cellular Pharmacology Department.
- The successful candidate will be responsible for supporting biochemical and cellular characterization of protein therapeutics for immuno-oncology.
- More specifically, the individual will develop, validate and execute biochemical and cell-based assays to characterize and screen biologic therapeutics in vitro and ex vivo, to support lead-finding/optimization efforts.
- Responsibilities include developing and implementing pharmacokinetic/pharmacodynamic assays and quantitating biomarkers.
- In addition, the candidate will function as part of a multi-disciplinary project team that will coordinate with Cancer Immunology, Protein Chemistry, Antibody Engineering, and Translational Oncology groups to advance lead molecules of the projects.
- Practical experience in the design, development, validation and execution of biochemical and cell-based assays to characterize protein therapeutics is required.
- Experience with multi-color flow cytometry, T cell functional assays, ELISA assays, culture of mammalian cell lines and primary immune cells is required.
- Experience with dendritic cell differentiation and culture is a plus.
- Experience with microscopy and/or high content image analysis is a plus.
- Familiarity with automated or semi-automated instrumentation, while not required, would be advantageous, as would familiarity with the multi-disciplinary activities of antibody lead profiling.
- Excellent teamwork, communication, time management, and organization skills.
- The qualified individual will possess a B.S. or M.S. degree in Immunology, Biochemistry, Cell Biology, or a related field with relevant immunology/immuno-oncology experience in academia, biotechnology and/or pharmaceutical industry.