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Pichia Pastoris Engineer

Lexington, KY 40511

Posted: 05/06/2025 Employment Type: Contract To Hire Industry: Scientific Job Number: 12130 Pay Rate: $60.00 - $80.00 Remote Friendly: Onsite

Job Description

About the Role:
  • Our client is seeking a highly skilled Pichia pastoris Engineer to join our growing team. This position focuses on fusion protein design, Pichia pastoris engineering, fermentation optimization and fusion protein purification. Initially part-time (approximately 20 hours/week) and remote, the role is expected to convert into a full-time, onsite position at the Lexington, KY facility within 2–3 months.
 
Key Responsibilities:
  • Design novel fusion proteins with desired biological activities
  • Genetically engineer Pichia pastoris yeast strains for precision fermentation and corresponding production of fusion proteins
  • Optimize yeast strains and fermentation conditions for efficient fusion protein production
  • Purify fusion proteins from fermentation supernatant using column chromatography
  • Scale-up of fermentation and fusion protein purification
  • Work independently with minimal supervision, maintaining close communication with the team

Top 3 Must-Have Skills:
  • Master’s degree or higher in Bioengineering, Molecular Biology, or Biomedical Engineering
  • 5–7+ years of experience in fusion protein design, yeast engineering, fusion protein purification and precision fermentation optimization and scale-up
  • Capability to span early stage R&D through scaleup for commercial production of fusion proteins

Job Requirements


Preferred Background and Requirements:
  • Hands-on experience designing fusion proteins and engineering Pichia pastoris
  • Demonstrated capability to optimize and scaleup fermentations
  • Strong collaboration and independent working skills

Red Flags:
  • Lack of direct hands-on experience with yeast-based production systems
  • Limited exposure to scale-up or manufacturing environments

Meet Your Recruiter

Melissa Politron
Recruiter

As a Compass Recruiter, Melissa "Mel" is excited about rediscovering her passion in helping candidates find opportunities that will excel their professional lives and improve their personal lives. She brings a deeply-rooted excitement to the team by understanding the people she works with and finding ways she can support them. Mel's connections with others inspires her to make a difference in the overall well being of her colleagues, candidates and clients alike. 

Outside of Compass, Mel enjoys cooking, dancing and being a mom to her three wonderful boys. She has an obsession with home organization and thoroughly enjoys solving other families' organizational needs. Mel is also very passionate about One Heart Source, a humanitarian organization that combats conditions such as poverty, diseases and illiteracy through education. She participated as a summer volunteer teacher in Tanzania and credits the organization for shaping her into the person she is today. 

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About Lexington, KY

Ready to embark on an exciting career in the vibrant Lexington, Kentucky area? Explore our job opportunities and unlock your professional potential in the Horse Capital of the World. Known for its rich history, picturesque horse farms, and thriving bourbon distilleries, Lexington offers a unique blend of Southern charm and modern opportunities for growth. Home to the famous Keeneland Race Track, the University of Kentucky Wildcats, and the Lexington Opera House, this area boasts a dynamic cultural scene that caters to diverse tastes. With its stunning Bluegrass landscapes, world-class cuisine, and lively entertainment venues, Lexington is truly a gem waiting to be discovered. Don't miss out on the chance to build your career in this enchanting region – browse our job listings today and take the first step towards an exciting future in Lexington!