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Fractional CSO/CMO

Simi Valley, CA 93063

Posted: 06/16/2025 Employment Type: Contract To Hire Industry: Research and Discovery Job Number: 12196 Pay Rate: $350.00 - $400.00 Remote Friendly: Remote

Job Description

Our client is a stealth startup committed to bringing the next generation of pharmaceutical treatments to combat cancer.


Job Title: Fractional Chief Scientific Officer / Chief Medical Officer (Hybrid Role)

Location: Remote / Hybrid

Time Commitment: Part-time / Fractional


About the Opportunity:
  • We are partnering with a stealth-mode, preclinical-stage biotechnology company advancing a first-in-class, small-molecule oncology therapeutic platform derived from a proprietary natural-compound chemical library.
  • With compelling in-vivo tumor eradication data and broad anti-tumor activity across multiple cancer models, the company is poised to move its lead candidate toward IND and first-in-human (FIH) studies.
  • They are seeking a fractional CSO/CMO hybrid who can provide strategic and hands-on leadership across preclinical development, translational planning, IND readiness, and early clinical design.

Key Responsibilities:
  • Lead the scientific and medical strategy from late-stage preclinical through IND-enabling studies and into FIH trial planning.
  • Guide mechanism-of-action studies, pharmacology, toxicology, and dose rationale in collaboration with discovery and translational teams.
  • Oversee CROs responsible for IND-enabling studies and ensure alignment with regulatory and clinical objectives.
  • Contribute to target product profile, clinical development plan, and biomarker strategy.
  • Work closely with company leadership on pipeline prioritization, scientific positioning, and external communications (including investors and potential partners).
  • Support preparation of regulatory documents and attend meetings with external stakeholders, as needed.?

Job Requirements

Qualifications:
  • MD required; oncology or related translational science background preferred.
  • 15+ years of experience in biotech/pharma, including roles with CSO, CMO, or VP-level responsibility.
  • Recent experience in small company (under 10).
  • Strong track record leading oncology programs from preclinical through IND and FIH studies.
  • Deep understanding of tumor biology, solid and hematologic malignancies, and translational strategy.
  • Demonstrated experience managing CROs and external scientific vendors in a resource-constrained, fast-paced environment.
  • Prior experience in early-stage biotech; comfortable operating in a lean, hands-on leadership role.

Why This Role?
  • Opportunity to drive a highly differentiated oncology therapeutic forward from discovery to clinic.
  • Strategic leadership role in a mission-driven, agile organization.
  • Flexible, fractional engagement designed for high-impact contributors.

Meet Your Recruiter

Lisa Weiss
Senior Recruiter, Account Manager

As a Recruiter at Compass, Lisa has a long history of working with candidates in many different industries. Lisa was drawn to the life science industry because she feels her best work is done when she’s connecting candidates to jobs that make a big impact on the world.

Lisa is passionate about her candidates and feels most rewarded when she helps them land their dream job. She will walk you through the opportunities and guide you so that you can share your best self to the employer.

When Lisa isn’t working, she enjoys fitness, travel, and spending time with her husband and two children.  And yes, if her voice sounds familiar to you it’s because she’s a famous voice over star.

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About Simi Valley, CA

Ready for a career change in Simi Valley, California? Seize the countless opportunities waiting for you in this vibrant region nestled in Ventura County. Simi Valley's picturesque landscapes, proximity to Los Angeles, and a thriving job market make it an ideal place to grow your career. From exploring the Ronald Reagan Presidential Library and Museum and hiking in the Santa Susana Mountains to enjoying the delectable cuisine at local eateries like Sutter's Mill and The Hat, Simi Valley offers a perfect blend of culture, nature, and entertainment. Don't miss out on joining this dynamic community – check out our job listings today and unlock your next career move!