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Computational Scientist II

South San Francisco, CA 94080

Posted: 07/07/2026 Employment Type: Contract Industry: Research and Discovery Job Number: 12727 Pay Rate: $47.00 - $63.00 Remote Friendly: Onsite

Job Description

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

About the Role:

We are seeking a highly motivated and collaborative Computational Scientist to join our team. The successful candidate will derive actionable insights from high-content perturbation screens of ex vivo systems. This role requires a deep understanding of computational methods for analyzing sequencing-based, multi-conditional perturbation data (e.g. Sci-plex, Perturb-seq, CROP-Seq), a passion for innovation, and a commitment to improving healthcare outcomes through cutting-edge technology.

Key Responsibilities:
  • Analyze large-scale high-content sequencing-based perturbation datasets
  • Collaborate with interdisciplinary and cross-functional teams including biologists, chemists, data scientists, and other stakeholders.

Job Requirements

Qualifications:
  • Educational Background: PhD degree in quantitative field (e.g., Computational Biology, Bioinformatics, Computer Science, Statistics, Mathematics) or in the physical or life sciences (e.g., Chemistry, Biology) with a strong quantitative focus.

Experience:
  • Proven track record of analyzing large-scale multi-conditional scRNA-seq datasets
  • Demonstrated interest in problems across biology and chemistry as applied to the discovery and development of treatments for disease.

Technical Skills:
  • Proficiency in scientific programming in Python.
  • Strong background in statistics, probabilistic modeling and data analysis.

Soft Skills: Excellent communication, collaboration, and problem-solving skills.

Publications: Strong publication record and experience contributing to research communities.

Preferred:
  • Experience with the analysis of Perturb-seq/CROP-seq data, or more generally with CRISPR data
  • Multimodal data integration, in particular between multiple measurement modalities and/or clinical patient data
  • Experience with workflow managers such as Nextflow or Snakemake
  • Practical experience with working on HPC systems / SLURM

Meet Your Recruiter

Jay Hite
Recruiter, Account Manager

As a Recruiter at Compass, Jay enjoys meeting job seekers and helping them to find new and exciting opportunities. He enjoys the process of getting to know candidates and learning all about their experience and what their future goals are. Jay feels the excitement of his candidates and is passionate about helping to find a fit both culturally and professionally. 

When Jay isn’t working, he enjoys bike rides, trying out new foods, tequila tasting and watching movies.  

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About South San Francisco, CA

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