Research Associate I

South San Francisco, California | Contract

Post Date: 10/23/2017 Job ID: 3475 Industry: Research

Our client is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. They  are among the world' s leading biotech companies, with multiple products on the market and a promising development pipeline.

 

Duties: 
  • This position is to investigate the pharmacokinetics, biodistribution, metabolism, and the PKPD relationships of novel therapeutics in preclinical setting in support of early and late stage drug development
  • The candidate will be responsible for designing and implementing in-vitro and in-vivo studies that includes cell based in-vitro assay, radiolabeled tissue distribution studies, ADME studies to understand the properties of antibody-drug conjugate (ADC) and protein therapeutics
  • The candidate will interact and develop close partnerships across various functions including Research, Safety Assessment, PD Biomarker, Bioanalytical Assays, Clinical Sciences, Formulation and Regulatory
  • Additional component of the job will be sample/data analysis and presentation of results to cross-functional teams, department meetings, review committees, internal/external conferences, and regulatory agencies
  • Design and implement in-vitro and in-vivo studies to address ADME questions of protein therapeutic and ADC. Writing and submitting protocol to cross functional team for review
  • Carry out sample analysis (including tissue processing) by using different analytical methods.
  • Characterize and identify possible biotransformation products from protein therapeutic and ADC in different biological matrices
  • Interpret data and communicate results in department meeting and project team meeting
  • Prepare presentation and report for conferences, manuscripts and regulatory documents

 

Skills:    
  • Candidate should be highly motivated individual with a passion for science, a curiosity of solving complex problem, attention to detail, as well as demonstrated effectiveness to work independently and in team settings
  • The candidate should also be proficient in a broad variety of lab related technical skills (cell culturing, cell base assay, analytical chemistry, etc.)
  • You are expected to have strong knowledge in basic pharmacology, drug metabolism/biodistribution and in PKPD relationship
  • An individual with strong communication and collaboration skill, along with the ability to clearly articulate solution
  • Must have demonstrated a general working knowledge of cell based assay, analytical techniques (HPLC, LSC, mass spectrometry and etc.), and laboratory skills. Ability to identify metabolite/catabolite and to elucidate metabolism pathway is preferred
  • Previous experience in chemistry, especially with working with radio-isotope, is a plus
  • Good oral and written communication skills are important as well as demonstrated effectiveness in working independently and in a team setting

 

Education:          
  • A Ph.D. in Pharmaceutical Sciences, Drug Metabolism, Pharmacology, Biochemistry or related discipline
  • 0-2 year of industry and/or post-doctoral experience is preferred
  • Bachelor’ s or Master’ s degree in Biology or Biochemistry with 5-10 years in the Research and Development experience may also qualified

 

 

Skills:    

  • Candidate should be highly motivated individual with a passion for science, a curiosity of solving complex problem, attention to detail, as well as demonstrated effectiveness to work independently and in team settings
  • The candidate should also be proficient in a broad variety of lab related technical skills (cell culturing, cell base assay, analytical chemistry, etc.)
  • You are expected to have strong knowledge in basic pharmacology, drug metabolism/biodistribution and in PKPD relationship
  • An individual with strong communication and collaboration skill, along with the ability to clearly articulate solution
  • Must have demonstrated a general working knowledge of cell based assay, analytical techniques (HPLC, LSC, mass spectrometry and etc.), and laboratory skills. Ability to identify metabolite/catabolite and to elucidate metabolism pathway is preferred
  • Previous experience in chemistry, especially with working with radio-isotope, is a plus
  • Good oral and written communication skills are important as well as demonstrated effectiveness in working independently and in a team setting

 

Education:          

  • A Ph.D. in Pharmaceutical Sciences, Drug Metabolism, Pharmacology, Biochemistry or related discipline
  • 0-2 year of industry and/or post-doctoral experience is preferred
  • Bachelor’s or Master’s degree in Biology or Biochemistry with 5-10 years in the Research and Development experience may also qualified

 

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